PNPLA3 Polymorphisms and Liver Aminotransferase Levels in a Mexican American Population
نویسندگان
چکیده
منابع مشابه
PNPLA3 polymorphisms and liver aminotransferase levels in a Mexican American population.
PURPOSE This study examined genetic associations of patatin-like phospholipase domain containing 3 gene (PNPLA3) polymorphisms and liver aminotransferases in an extensively documented, randomly recruited Mexican American population at high risk of liver disease. METHODS Two single nucleotide polymorphisms (SNP) in the PNPLA3 gene (i.e., rs738409 and rs2281135) were genotyped in 1532 individua...
متن کاملAncestral Effect on HOMA-IR Levels Quantitated in an American Population of Mexican Origin
OBJECTIVE An elevated insulin resistance index (homeostasis model assessment of insulin resistance [HOMA-IR]) is more commonly seen in the Mexican American population than in European populations. We report quantitative ancestral effects within a Mexican American population, and we correlate ancestral components with HOMA-IR. RESEARCH DESIGN AND METHODS We performed ancestral analysis in 1,55...
متن کاملSerum aminotransferase levels in healthy population from western India
BACKGROUND & OBJECTIVES Serum alanine aminotransferase (ALT) level is most commonly used as a marker for the assessment of various liver diseases. Currently upper limits of normal for aspartate aminotransferase (AST) or ALT levels used are based on the western literature. This study was conducted to determine the ALT and AST levels in healthy blood donors from western India and to determine the...
متن کاملAnaphylaxis Associated with Peanuts and Nuts in Late Mexican Adolescents: A Population Based Study
Background: There is a lack of information regarding anaphylaxis that is triggered by the peanut and nuts in countries with emerging economies. We aimed to identify the factors that are related to the prevalence of secondary anaphylaxis that results from ingesting peanuts or nuts. Materials and Methods: A cross-sectional, population-based study was conducted in which we applied a structured qu...
متن کاملPNPLA3 I148M polymorphism and progressive liver disease.
The 148 Isoleucine to Methionine protein variant (I148M) of patatin-like phospholipase domain-containing 3 (PNPLA3), a protein is expressed in the liver and is involved in lipid metabolism, has recently been identified as a major determinant of liver fat content. Several studies confirmed that the I148M variant predisposes towards the full spectrum of liver damage associated with fatty liver: f...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical & Investigative Medicine
سال: 2012
ISSN: 1488-2353
DOI: 10.25011/cim.v35i4.17153